Cirrhosis Surveillance Protocol

Based on recommendations from the British Society of Gastroenterology (BSG) and National Institute for Health and Care Excellence (NICE), simplified into:

👉 what you actually need to organise in clinic or on discharge
👉 not long guideline documents

Because once a patient has cirrhosis, your job changes from:

❌ “treat the liver disease”
to
✅ “prevent complications and detect cancer early”

Surveillance is what prevents deaths.


✅ Why surveillance matters

Cirrhosis patients are at risk of:

  • Hepatocellular carcinoma (HCC)
  • Variceal bleeding
  • Ascites/SBP
  • Encephalopathy
  • Renal failure

Many of these are:
👉 silent until late

So we screen regularly.


✅ First principle

Think:

Every cirrhosis patient needs routine surveillance, even if they feel well.

Normal symptoms ≠ low risk.



🔴 1. HCC (liver cancer) surveillance – MOST IMPORTANT

This is the one you must never forget.

Cirrhosis = high HCC risk.

Early cancer is treatable.
Late cancer isn’t.


Who needs it?

👉 ALL patients with cirrhosis
(regardless of cause: alcohol, MASLD, hep B/C, autoimmune, etc.)


What to do?

Every 6 months:

  • Liver ultrasound
  • AFP blood test (optional but commonly used)

That’s it.

Simple.


Why 6 months?

Because:

  • cancers grow fast
  • yearly is too late
  • 3 months unnecessary

So:
👉 6 months is the standard interval


Practical tip

When discharging:
👉 always check “next ultrasound booked?”

Very commonly missed.



🔴 2. Variceal surveillance (portal hypertension)

Prevents catastrophic bleeds.


Who needs OGD?

At diagnosis of cirrhosis:
👉 baseline OGD to look for varices


Then:

No varices

Repeat every 2–3 years


Small varices

Repeat every 1–2 years


Large varices

Start:

  • non-selective beta blocker (carvedilol/propranolol)
    OR
  • band ligation

No routine surveillance only — needs treatment.


Practical ward thinking

If you see:
“Cirrhosis – never scoped”

👉 they need OGD referral



🟡 3. Routine blood monitoring

Done regularly in clinic/GP.

Usually every 6–12 months.


Check:

  • FBC
  • U&E
  • LFTs
  • INR
  • Albumin

Why?

Helps detect:

  • worsening synthetic function
  • decompensation
  • renal issues

Trends matter more than single results.



🟡 4. Vaccinations (often forgotten)

All cirrhosis patients should have:

  • Hep A
  • Hep B
  • Flu
  • Pneumococcal

Because infection risk is higher and outcomes worse.

Easy win. Often missed.



🟡 5. Lifestyle + prevention

Simple but important.

Advise:

  • alcohol cessation
  • weight loss (MASLD)
  • diabetes control
  • avoid NSAIDs
  • careful with nephrotoxic drugs

Prevents decompensation.



🔴 6. Watch for decompensation

Surveillance isn’t just tests — it’s recognising deterioration.


Red flags

  • Ascites
  • Encephalopathy
  • GI bleeding
  • Jaundice
  • AKI
  • Recurrent admissions

If present:
👉 urgent hepatology review

Not routine follow-up.



✅ Practical ward/clinic scenarios


Scenario 1

Stable alcoholic cirrhosis
→ 6-monthly US ± AFP
→ OGD schedule


Scenario 2

No varices on first OGD
→ repeat in 2–3 years


Scenario 3

Large varices found
→ beta blocker/banding
→ not just surveillance


Scenario 4

Missed ultrasound for 2 years
→ rebook urgently


Scenario 5

New ascites
→ decompensation
→ admission/workup, not routine clinic



✅ What juniors should check on ward round

For every cirrhosis patient, ask:

  • Last ultrasound?
  • Last OGD?
  • On beta blocker?
  • Vaccinated?
  • Any decompensation?

If you check these five things, you’re doing good hepatology care.



❌ Common junior mistakes

  • Forgetting HCC surveillance
  • Thinking “they look well so no scan needed”
  • Not arranging OGD
  • Ignoring vaccinations
  • Missing early decompensation
  • Discharging without follow-up booked

Most harm is from missed follow-up, not missed drugs.



✅ Simple memory rule

Cirrhosis = 3 things to remember

👉 Scan every 6 months
👉 Scope for varices
👉 Monitor bloods

Everything else is secondary.



✅ Take-home concept

Cirrhosis care is proactive, not reactive.
Regular surveillance prevents bleeds and cancer.

If you only remember ultrasound every 6 months, you’ll already save lives.